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change in that environment. we have learned through a variety of approaches things that we probably didn't expect would be now in front of us this soon. for instance, what are the hereditary factors involved in this disease? it clearly runs in families. we have gone from knowing sort of one risk factor for the late onset type of alzheimer's disease to now depending on who you ask 19 or 20 that we have. that number is growing. in fact, it will be growing rapidly this coming year in part because of the fy-'14 appropriation because we're expanding our ability to do that kind of genetic analysis. we have gone from understanding that amyloid was a player to understanding a lot more about tau and to be able to look at pathways in the brain that are really quite complex and point to other sort of nodes in those pathways that are really important and might be drugable. we have gone from having a few clinical trials focused largely on advanced cases of alzheimer's to what you heard about today, where we now, because we can make the prediction about high risk, start the treatment earlier. just lik
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